高福 -中科院院士,中國疾病預防控製中心副主任

高福

中科院院士,中國疾病預防控製中心副主任
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高福(George Fu Gao),1961年11月15日出生于山西省應縣。英國牛津大學博士(DPhil (Oxon))。中國科學院微生物研究所所長,中國科學院病原微生物與免疫學重點實驗室主任,研究員,博士生導師,"中國科學院"百人計畫"入選者,國家傑出青年基金"得主,"國家973項目"首席科學家,中國生物工程學會常務副理事長,歐美同學會留英分會副會長。2010年至今任牛津大學客座教授。2011年5月至今任中國疾病預防控製中心副主任。2013年12月當選中國科學院院士。

長期從事病原微生物與免疫學領域研究,特別是在病原與宿主的相互識別和相互作用方面進行了系統性和原創性工作。揭示了包括流感病毒、冠狀病毒等在內的重要囊膜病毒侵入、融合和釋放機製,為新一代抗病毒葯物開發提供潛在靶標;揭示了重要病原跨宿主傳播與致病機製,尤其是H5N1和H7N9禽流感病毒突破種間屏障的生態學與分子機製;揭示了CD8等重要免疫分子受體與配體的互作機製以及流感等重要病原細胞免疫機製。曾獲開發中國家科學院(TWAS)基礎醫學獎等獎項

  • 中文名稱
    高福
  • 外文名稱
    George Fu Gao
  • 國籍
    中國
  • 民族
    漢族
  • 出生地
    山西省應縣
  • 出生日期
    1961年11月15日
  • 職業
    中國科學院院士
  • 畢業院校
    山西農業大學 中國農業大學 牛津大學 卡爾加裏大學 哈佛大學
  • 主要成就
    中國科學院微生物研究所所長,中國科學院院士

研究領域

病原微生物與免疫學, 主要研究病原微生物與宿主互作及宿主免疫識別過程中相關的蛋白質結構與功能。 分子免疫學領域:集中研究T細胞免疫中分子識別的蛋白質與蛋白質的相互作用,尤其是細胞介面的表面蛋白質(受體與配體)之間的相互作用。

高福

分子病毒學領域:囊膜病毒侵入的分子機製,尤其是細胞受體與病毒囊膜蛋白相互作用及融合抑製劑的葯物設計。

分子流行病學與分子進化:近幾年來,聯合國內其他優勢單位,對野生水禽感染禽流感、人感染2型豬鏈球菌、豬的無名高熱等傳染病進行了系統研究。

教育背景

1979 - 1983, 山西農業大學,學士,獸醫學。

高福

1983 - 1986, 北京農業大學,碩士,微生物學與動物傳染病學。

1991-1994 年 英國牛津大學 博士 ( DPhil-Oxon )(師從 David H L Bishop, Ernest A Gould ),生物化學

1994 年(3個月) 加拿大 Calgary University 博士後(師從 Robert Bell )

1995-1998 年 英國牛津大學 博士後(師從 John I bell, Andrew J McMichael, Bent K Jakobsen )

1999-2001 年 美國哈佛大學 / 哈佛醫學院 博士後(師從 Don C Wiley, Stephen C Harrison )(工作期間資助:英國 Wellcome Trust International Travelling Fellow )

2001-2004 年 英國牛津大學 講師、博士生導師、 Group leader

工作經歷

1986-1991 年 北京農業大學 助教 / 講師 1994 年(3個月) 加拿大 Calgary University 博士後(師從 Robert Bell )

高福

1995-1998 年 英國牛津大學 博士後(師從 John I bell, Andrew J McMichael, Bent K Jakobsen )

1999-2001 年 美國哈佛大學 / 哈佛醫學院 博士後(師從 Don C Wiley, Stephen C Harrison )(工作期間資助:英國 Wellcome Trust International Travelling Fellow )

2001-2004 年 英國牛津大學 講師、博士生導師、 Group leader

2004 -2008年中國科學院微生物研究所 所長

2004-至今 中國科學院微生物研究所 研究員、博士生導師

2008-至今 中國科學院北京生命科學研究院 副院長,中國科學院病原微生物與免疫學重點實驗室 主任

2010-至今 英國牛津大學 客座教授

2011-至今 中國疾病預防控製中心 副主任

2013年12月當選中國科學院院士。

社會兼職

2012-01--今 《Philosophical Transactions of the Royal Society B: Biological Sciences》雜志

2011-10--今 中國微生物學會病毒學專業委員會 ,副主任委員

高福

2011-06--今 中國科學技術協會,第八屆常委

2010-12--今 中國生物工程學會,第五屆理事會副理事長

2015-11--今 中國生物工程學會,第六屆理事會理事長

2010-10--今 中國免疫學會

2010-01--今 《Protein & Cell》雜志

2010-01--今 牛津大學,客座教授

2009-01--今 《Experimental Biology and Medicine》雜志

2006-06--今 國際抗病毒聯盟(ICAV)

出版信息

發表論文

(1) Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4,Nature Structural and Molecular Biology,2013,通訊作者

(2) Origin and diversity of novel H7N9 avian influenza viruses causing human infecions,The Lancet,2013,通訊作者

(3) An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level,Science,2013,通訊作者

(4) Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and likely uses a unique entry mechanism,Cell Reports,2013,通訊作者

(5) Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors,Nature Communications,2013,通訊作者

(6) Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226,Journal of Immunology,2012,通訊作者

(7) The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism.,Microbiology,2012,通訊作者

(8) The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism,Microbiology,2012,通訊作者

(9) Genomic and antigenic characterization of the newly-emerging Chinese duck egg-drop syndrome flavivirus: genomic comparison with Tembusu and Sitiawan viruses,Journal of General Virology,2012,通訊作者

(10) Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226,The Journal of Immunology,2012,通訊作者

(11) Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus,Proceedings of the National Academy of Sciences of the United States of America (PNAS),2012,通訊作者

(12) Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China,PLoS ONE,2012,通訊作者

(13) Type-IVC Secretion system: A novel subclass of type IV secretion system (T4SS) common existing in gram-positive genus Streptococcus,PLoS ONE,2012,通訊作者

(14) Reply to Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1--Sequence sharing between viral nuclear export signals (NES) and CD8+ T cell epitopes,Journal of Virology,2012,通訊作者

(15) Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens,The Journal of Immunology,2012,通訊作者

(16) An octamer of enolase from Streptococcus suis,Protein and Cell,2012,通訊作者

(17) Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of H16 subtype has an a-helix structure in its cleavage site with an inefficient HA1/HA2 cleavage,Journal of Virology,2012,通訊作者

(18) Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals,Journal of Virology,2012,通訊作者

(19) Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis,Journal of Infection,2012,通訊作者

(20) Insight into the interaction of metal ions with TroA from Streptococcus suis,PLoS ONE,2011,通訊作者

(21) A novel "open-form" structure of sortaseC from Streptococcus suis,Proteins: Structure, Function, and Bioinformatics,2011,通訊作者

(22) 我國發現的一種引起鴨產蛋下降綜合征的新型黃病毒,中國獸醫雜志,2011,通訊作者

(23) 合成病毒:對流感病毒研究的貢獻,生命科學,2011,通訊作者

(24) T細胞功能學與結構免疫學結合方法鑒定HLA-A2限製性的細胞毒性T淋巴細胞表位富集區,科技導報,2011,通訊作者

(25) A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment,Journal of Central South University of Technology,2011,通訊作者

(26) Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability,Science China Life Sciences,2011,通訊作者

(27) An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: topology of glycoprotein 3 (GP3) addressing the intrachain disulfide bonds; PRRSV infectious clone and GP3 topology,Chinese Science Bulletin,2011,通訊作者

(28) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase (invited review),Chinese Science Bulletin,2011,通訊作者

(29) Revival of the identification of cytotoxic T-lymphocyte epitopes for immunological diagnosis therapy and vaccine development,Experimental Biology and Medicine,2011,通訊作者

(30) Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays,BMC Genomics,2011,通訊作者

(31) Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes,Molecular Immunology,2011,通訊作者

(32) Plasticity of human CD8αα binding to peptide-HLA-A*2402,Molecular Immunology,2011,通訊作者

(33) Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions,PLoS ONE,2011,通訊作者

(34) Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the viral ribonucleoprotein complex,PLoS ONE,2011,通訊作者

(35) LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence,PLoS ONE,2011,通訊作者

(36) Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus,PLoS ONE,2011,通訊作者

(37) Clade 2.3.2 avian influenza virus (H5N1), Qinghai Lake region, China, 2009–2010,Emerging Infectious Diseases,2011,通訊作者

(38) GI-type T4SS mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2,Molecular Microbiology,2011,通訊作者

(39) Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of 2009 Pandemic Swine-Origin Influenza A H1N1 Virus Cytotoxic T Lymphocyte Epitope Peptides,Journal of Virology,2011,通訊作者

(40) A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes, BMC Microbiology,2011,通訊作者

(41) 小議2010國內外生命科學重要進展,遺傳,2011,通訊作者

(42) Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition, PLoS Pathogens,2011,通訊作者

(43) Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Nature Communications,2011,通訊作者

(44) Structural basis of diverse peptide accommodation by the Rhesus Macaque MHC class I molecule Mamu-B*17: insights into immune protection from simian immunodeficiency virus,Journal of Immunology,2011,通訊作者

(45) Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance,Journal of Biological Chemistry ,2011,通訊作者

(46) Two distinct conformations of a CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801: a host strategy for presentation of a featured peptide,Journal of Virology,2011,通訊作者

(47) Diverse peptide presentation of Rhesus Macaque major histocompatibility complex class I Mamu-A*02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus, Journal of Virology,2011,通訊作者

(48) Influenza A virus neuraminidase N5 has an extended 150-cavity,Journal of Virology,2011,通訊作者

(49) Enterovirus 71 and Coxsackievirus A16 3C proteases: binding to Rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design,Journal of Virology,2011,通訊作者

(50) 從人類基因組到人造生命:克雷格文特爾領路生命科學,生物工程學報,2010,通訊作者

(51) 天然免疫抗病毒效應分子Mx 蛋白的結構與功能研究進展,生物化學與生物物理進展,2010,通訊作者

(52) It is not just AIV: From avian to swine-origin influenza virus,Science China Life Sciences,2010,通訊作者

(53) In-silicon characterization of the functional and structural modules of the haemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009,Science China Life Sciences,2010,通訊作者

(54) Serological surveillance of influenza A virus infection in swine populations in Fujian Province, China: no evidence of naturally occurring H5N1 infection in pigs,Zoonoses and Public Health,2010,通訊作者

(55) Identification and structural definition of H5-specific CTL epitopes restricted by HLA-A*0201 derived from H5N1 subtype of influenza A viruses, Journal of General Virology,2010,通訊作者

(56) Galanin protects against intracellular amyloid toxicity in human primary neurons,Journal of Alzheimer's Disease,2010,通訊作者

(57) Crystal structure of EHEC intimin: insights into the complementarity between EPEC and EHEC,PLoS ONE,2010,通訊作者

(58) 基于結構的抗流感病毒神經氨酸酶抑製劑的設計和研發,醫葯生物技術,2010,通訊作者

(59) Genetic correlation between current circulating H1N1 swine and human influenza viruses,Journal of Clinical Virology,2010,通訊作者

(60) Detection of avian influenza virus subtype H5 using a biosensor based on imaging ellipsometry,Biosensors and Bioelectronics,2010,通訊作者

(61) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site.,Nature Structural and Molecular Biology,2010,通訊作者

(62) A dimeric structure of PD-L1: functional units or evolutionary relics,Protein and Cell,2010,通訊作者

(63) Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus,Protein and Cell,2010,通訊作者

(64) Na+/K+-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication,Science China Life Sciences,2010,通訊作者

(65) Novel immunodominant peptide presentation strategy: a featured HLA-A*2402 restricted CTL-epitope stabilized by intra-chain hydrogen-bonds from SARS-CoV N protein,Journal of Virology,2010,通訊作者

(66) Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent,Trends in Microbiology,2010,通訊作者

(67) The membrane protein of SARS-CoV acts as a dominant immunogen revealed by a clustering region of novel functional and structural defined CTL epitopes,The Journal of Infectious Diseases,2010,通訊作者

(68) Revival of gene therapy,Protein and Cell,2010,通訊作者

(69) Interspecies transmission and host restriction of avian H5N1 influenza virus,Science China Life Sciences,2009,通訊作者

(70) 動物源性流感病毒與人流感流行,科技導報,2009,通訊作者

(71) Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: crystal structures of the substrate-free and quaternary complex enzymes,Protein Science,2009,通訊作者

(72) Stable non-synonymous substitutions on NS gene (NS1 and NS2 proteins) of Qinghai Lake H5N1 influenza virus (Clade 2.2) after successive passages in Muscovy ducks,Science China Series C: Life Science,2009,通訊作者

(73) MyBASE: a database for genome polymorphism and gene function studies of Mycobacterium,BMC Microbiology,2009,通訊作者

(74) Avian influenza virus, Streptococcus suis serotype 2, SARS-coronavirus and beyond: molecular epidemiology, ecology and the situation in China,Philosophical Transactions of the Royal Society B (Biological Sciences),2009,通訊作者

(75) Structure and cleavage-specificity of the chymotrypsin-like serine protease (3CLSP/nsp4) of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV),Journal of Molecular Biology,2009,通訊作者

(76) Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism,Journal of Bacteriology,2009,通訊作者

(77) The challenges of avian influenza virus: mechanism, epidemiology and control,Science China Life Sciences,2009,通訊作者

(78) Autophagy is involved in influenza A virus replication,Autophagy,2009,通訊作者

(79) 恆河猴MHC-I類分子Mamu-A*02與SIV抗原表位復合物的純化和晶體學研究,生物工程學報,2009,通訊作者

(80) 雞β2-微球蛋白及其硒代衍生物的製備和晶體學研究,科技導報,2009,通訊作者

(81) Structural immunology and crystallography help immunologists see the immune system in action: How T and NK cells touch their ligands,IUBMB Life,2009,通訊作者

(82) Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes,Journal of Molecular Biology,2009,通訊作者

(83) Rhesus macaque: a tight homodimeric CD8??,Proteins: Structure, Function, and Bioinformatics,2009,通訊作者

(84) Analysis of hemagglutinin-mediated entry tropism of H5N1 avian influenza,Virology Journal,2009,通訊作者

(85) Website for avian flu information and bioinformatics,Science China Life Sciences,2009,通訊作者

發表著作

(1) 免疫學前沿進展 (第二版) 第七章: 結構免疫學研究進展: 主要組織相容性復合物的分子識別,Frontier Progress of Immunology (Edition 2) Chapter 7 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民衛生出版社,2011-12,第3作者

(2) 主要組織相容性復合物與多肽的相互作用,Major Histocompatibility Complex: Interaction with Peptides,John Wiley and Sons, Ltd,2011-08,第2作者

(3) 套用于健康、環境及生物安全的生物感測器 第七章:套用于人類健康的無標記生物感測器,Biosensors for Health, Environment and Biosecurity Chapter 7: Label-free Biosensors for Health Applications,InTech,2011-07,第1作者

(4) 免疫學前沿進展(第一版) 第六章: 結構免疫學研究進展: 主要組織相容性復合物的分子識別,Frontier Progress of Immunology (Edition 1) Chapter 6 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民衛生出版社,2009-12,第3作者科研活動

科研項目

(1) Follow-up of Surveillance of the Wild Birds and Pl,主持,其他級,2011-12--2012-11

(2) 新型免疫細胞δβ T細胞識別配體的功能和結構基礎,主持,部委級,2011-01--2014-12

(3) 重要病毒跨種間感染與傳播致病的分子機製研究,主持,部委級,2011-01--2015-12

(4) 病原微生物與宿主互作的分子機製,主持,部委級,2011-01--2013-12

(5) 獲得性免疫的起源與演化,參與,部委級,2011-01--2013-12

參與會議

(1) Special characteristics of the 2009-pandemic H1N1 influenza A virus hemagglutinin and neuraminidase,2012-04,高福

(2) Nectin and nectin-like molecules: Adhesion, immune,2012-04,高福

(3) 2009 Pandemic influenza virus: what special for its HA and NA,2012-01,高福

(4) Making the CTL-epitopes featured for T cell recognition,2011國際免疫暨腫瘤研討會,2011-12,高福

(5) 創新:永遠的追求--我所認識的田波院士,第九屆全國病毒學學術研討會,2011-09,高福

(6) 分會主席,2011-09,分會主席

(7) ILT: Differential Binding to HLA,第二屆海峽兩岸四地免疫學研討會,2011-08,高福

(8) T-cell-based immunotherapy,第五屆中國生物產業大會,2011-06,高福

(9) 2009 Pandemic influenza virus: what special for its HA and NA,2011-06,高福

(10) Study of CTL-based cellular immunity against severe acute respiratory syndrome coronavirus,2011-06,高福

(11) 2009 Pandemic influenza virus: what special for its HA and NA,2011-01,高福

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