吳瑛 -千人計畫特聘專家

吳瑛

吳瑛:中科院生物物理所腦與認知科學國家重點實驗室研究員。2010年成為中央"千人計畫"特聘專家,中科院生物物理所創新課題組組長,高級顧問研究員 。

主要研究方向是揭示參與神經發育和神經推行性病變的基因調控的分子機製 。

  • 中文名
    吳瑛
  • 國籍
    中國
  • 職業
    教師
  • 畢業院校
    美國斯坦福大學

人物簡介

吳瑛,博士。美國西北大學講席教授。

吳瑛

1980-1986年上海醫科大學醫學士;

1986-1991年美國斯坦福大學腫瘤生物學博士;

1991-1994年哈佛大學生物化學和分子生物學系博士後。

先後任教于華盛頓大學醫學院、範德比爾特大學醫學中心、西北大學神經生物學系。

人物經歷

1980-1986 上海醫科大學,醫學學士

1986-1991 美國斯坦福大學,博士

1991-1994 美國哈佛大學,博士後

1994-2003 美國華盛頓大學醫學院,助理教授、副教授

2003-2005 美國Vanderbilt大學,教授

2005- 美國西北大學醫學院,Lurie 癌症中心,Charles Luis Mix 教授

2008- 中國科學院生物物理研究所,高級顧問研究員

獲得榮譽

曾獲美國白血病學會連續十二年資助(從博士後、特別研究員到學者獎)。為Science、Nature、Cell、MCB、PNAS等15個雜志審稿,為美國國立健康研究院、老年痴呆基金會、加拿大醫學研究委員會、義大利Telethon基金會等評審基金。在哈佛大學參與生物化學教學、在華盛頓大學參與核酸與蛋白質、細胞生物學博士生課程教學, 在英國劍橋、美國哈佛大學、賓州大學、布朗大學等做過學術報告。1998年起兼上海醫科大學教授。曾獲上海醫科大學一等獎(1986年)和國家傑出青年科學基金(1998年), 2001年起參與中國科學院上海生命科學研究院分子生物學研究生課程教學。研究領域:mRNA剪接、神經退行性病變的分子機理和白細胞遷移。

學術成果

論文發表于Cell、Nature、Science、MCB、J.Neuroscience,、JBC。曾獲美國白血病學會連續十二年資助(從博士後、特別研究員到學者獎)。為Science、Nature、Cell、MCB、PNAS等15個雜志審稿,為美國國立健康研究院、老年痴呆基金會、加拿大醫學研究委員會、義大利Telethon基金會等評審基金。在哈佛大學參與生物化學教學、在華盛頓大學參與核酸與蛋白質、細胞生物學博士生課程教學, 在英國劍橋、美國哈佛大學、賓州大學、布朗大學等做過學術報告。1998年起兼上海醫科大學教授。曾獲上海醫科大學一等獎(1986年)和國家傑出青年科學基金(1998年), 2001年起參與中國科學院上海生命科學研究院分子生物學研究生課程教學。現任美國西北大學講座教授,北京清華大學長江講座教授,中國科學院生物物理研究所研究員。吳瑛以研究RNA剪接的分子生物學著名。曾獲中國國家自然科學基金委員會“國家傑出青年基金”B類。

代表論文

1: Moodley Y, Linz B, Yamaoka Y, Windsor HM, Breurec S, Wu JY, Maady A, Bernh?ft S, Thiberge JM, Phuanukoonnon S, Jobb G, Siba P, Graham DY, Marshall BJ, Achtman M.(2009)The peopling of the Pacific from a bacterial perspective.Science. 323(5913):527-30.

2:Fushimi K, Ray P, Kar A, Wang L, Sutherland LC, Wu JY.(2008)Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.Proc Natl Acad Sci U S A. 105(41):15708-13.

3:Wang C, Norton JT, Ghosh S, Kim J, Fushimi K, Wu JY, Stack MS, Huang S.(2008)Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner.J Biol Chem. 283(29):20277-87.

4:Havlioglu N, Wang J, Fushimi K, Vibranovski MD, Kan Z, Gish W, Fedorov A, Long M,Wu JY.(2007)An intronic signal for alternative splicing in the human genome.PLoS ONE. 2(11):e1246.

5:Yang YC, Ho TC, Chen SL, Lai HY, Wu JY, Tsao YP.(2007)Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.BMC Cancer.7:216.

6:Yang G, Huang SC, Wu JY, Benz EJ Jr.(2008)Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.Blood.111(1):392-401.

7:Altay T, McLaughlin B, Wu JY, Park TS, Gidday JM.(2007)Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia.Exp Neurol.207(2):186-94.

8:Mordes D, Yuan L, Xu L, Kawada M, Molday RS, Wu JY.(2007)Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa.Neurobiol Dis.26(2):291-300.

9:Mordes D, Luo X, Kar A, Kuo D, Xu L, Fushimi K, Yu G, Sternberg P Jr, Wu JY.(2006)Pre-mRNA splicing and retinitis pigmentosa.Mol Vis.12:1259-71.

10:Wu JY, Kar A, Kuo D, Yu B, Havlioglu N.(2006)SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy.Mol Cell Biol.26(18):6739-47.

11:Li X, Chen Y, Liu Y, Gao J, Gao F, Bartlam M, Wu JY, Rao Z.(2006)Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.J Biol Chem.281(38):28430-7.

12:Donahue CP, Muratore C, Wu JY, Kosik KS, Wolfe MS.(2006)Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.J Biol Chem. 281(33):23302-6.

13:Kar A, Havlioglu N, Tarn WY, Wu JY.(2006)RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.J Biol Chem.281(34):24479-88.

14:Kar A, Kuo D, He R, Zhou J, Wu JY.(2005)Tau alternative splicing and frontotemporal dementia.Alzheimer Dis Assoc Disord. Oct-Dec;19 Suppl 1:S29-36. Review.

15:Yuan L, Kawada M, Havlioglu N, Tang H, Wu JY.(2005)Mutations in PRPF31 inhibit pre-mRNA splicing of rhodopsin gene and cause apoptosis of retinal cells.J Neurosci.25(3):748-57.

16:Chen B, Blair DG, Plisov S, Vasiliev G, Perantoni AO, Chen Q, Athanasiou M, Wu JY, Oppenheim JJ, Yang D.(2004)Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis.J Immunol. 173(10):5914-7.

17:Yang G, Huang SC, Wu JY, Benz EJ Jr.(2005)An erythroid differentiation-specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer.Blood.105(5):2146-53.

18:Kanellis J, Garcia GE, Li P, Parra G, Wilson CB, Rao Y, Han S, Smith CW, Johnson RJ, Wu JY, Feng L.(2004)Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis.Am J Pathol. 165(1):341-52.

19:Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, Kevil C, Xiong WC, Elmets C, Rao Y, Wu JY, Xu H.(2003)Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses.J Immunol. 171(12):6519-26.

20:Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY.(2003)Robo4 is a vascular-specific receptor that inhibits endothelial migration.Dev Biol.261(1):251-67.

21:Ward M, McCann C, DeWulf M, Wu JY, Rao Y.(2003)Distinguishing between directional guidance and motility regulation in neuronal migration.J Neurosci. 23(12):5170-7.

22:Sobrido MJ, Miller BL, Havlioglu N, Zhukareva V, Jiang Z, Nasreddine ZS, Lee VM, Chow TW, Wilhelmsen KC, Cummings JL, Wu JY, Geschwind DH.(2003)Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia.Arch Neurol. 60(5):698-702.

23:Jiang Z, Tang H, Havlioglu N, Zhang X, Stamm S, Yan R, Wu JY.(2003)Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta.J Biol Chem. 278(21):18997-9007.

24:Anselmo MA, Dalvin S, Prodhan P, Komatsuzaki K, Aidlen JT, Schnitzer JJ, Wu JY, Kinane TB.(2003)Slit and robo: expression patterns in lung development.Gene Expr Patterns. 2003 Mar;3(1):13-9.

25:Wu JY, Tang H, Havlioglu N.(2003)Alternative pre-mRNA splicing and regulation of programmed cell death.Prog Mol Subcell Biol. 2003;31:153-85. Review.

26:Havlioglu N, Yuan L, Tang H, Wu JY.(2002)Slit proteins, potential endogenous modulators of inflammation.J Neurovirol. 2002 Dec;8(6):486-95. Review.

27:Rao Y, Wong K, Ward M, Jurgensen C, Wu JY.(2002)Neuronal migration and molecular conservation with leukocyte chemotaxis.Genes Dev. 16(23):2973-84. Review.

28:Wong K, Park HT, Wu JY, Rao Y.(2002)Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.Curr Opin Genet Dev. 12(5):583-91. Review.

29:Zhu Y, Yu T, Zhang XC, Nagasawa T, Wu JY, Rao Y.(2002)Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.Nat Neurosci. 5(8):719-20.

30:Wu JY, Shu SG, Yang CF, Lee CC, Tsai FJ.(2002)Mutation analysis of thyroid peroxidase gene in Chinese patients with total iodide organification defect: identification of five novel mutations.J Endocrinol. 172(3):627-35.

31:Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y.(2001)Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.Cell. 107(2):209-21.

32:Rao Y, Wu JY.(2001)Neuronal migration and the evolution of the human brain.Nat Neurosci. 4(9):860-2.

33:Wu JY, Feng L, Park HT, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Zh, Zhang Xc, Rao Y.(2001)The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors.Nature. 410(6831):948-52.

34:Chen JH, Wen L, Dupuis S, Wu JY, Rao Y.(2001)The N-terminal leucine-rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons.J Neurosci. 21(5):1548-56.

35:Coté J, Dupuis S, Jiang Z, Wu JY.(2001)Caspase-2 pre-mRNA alternative splicing: Identification of an intronic element containing a decoy 3' acceptor site.Proc Natl Acad Sci U S A. 98(3):938-43.

36:C?té J, Dupuis S, Wu JY.(2001)Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion.J Biol Chem.276(11):8535-43.

37:Jiang Z, Cote J, Kwon JM, Goate AM, Wu JY.(2000)Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17.Mol Cell Biol.20(11):4036-48.

38:Yuan W, Zhou L, Chen JH, Wu JY, Rao Y, Ornitz DM.(1999)The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.Dev Biol. 212(2):290-306.

39:Zhu Y, Li H, Zhou L, Wu JY, Rao Y.(1999)Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex.Neuron. 23(3):473-85.

40:Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y.(1999)Directional guidance of neuronal migration in the olfactory system by the protein Slit.Nature. 400(6742):331-6.

41:Jiang ZH, Wu JY.(1999)Alternative splicing and programmed cell death.Proc Soc Exp Biol Med. 220(2):64-72. Review.

42:Jiang ZH, Zhang WJ, Rao Y, Wu JY.(1998)Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors.Proc Natl Acad Sci U S A.95(16):9155-60.

43:Zhang WJ, Wu JY.(1998)Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.Mol Cell Biol. 18(2):676-84.

44:Powell DM, Amaral MC, Wu JY, Maniatis T, Greene WC.(1997)HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing.Proc Natl Acad Sci U S A. 94(3):973-8.

45:Li H, Tierney C, Wen L, Wu JY, Rao Y.(1997)A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate.Development. 124(3):603-15.

46:Zhang WJ, Wu JY.(1996)Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.Mol Cell Biol. 16(10):5400-8.

47:Bao Y, Kishnani P, Wu JY, Chen YT.(1996)Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene.J Clin Invest. 97(4):941-8.

48:Wu JY, Maniatis T.(1993)Specific interactions between proteins implicated in splice site selection and regulated alternative splicing.Cell.75(6):1061-70.

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